178 papers
This study introduces and validates the novel Risky Social Choices task, demonstrating that in a general population, impulsive decision-making is uniquely predicted by reduced accuracy in recognizing implicit negative long-term consequences and heightened approach motivation for short-term rewards.
This study reveals that while witnessed and physical trauma strongly predict PTSD and functional impairment among stateless refugee children in Nigeria, emotional and sexual trauma specifically drive CPTSD symptoms, with the protective effect of teacher support against self-organization disturbances being significantly contingent on the children's proficiency in the Nigerian language.
Using data from a large longitudinal cohort, this study identifies four distinct night-time sleep duration trajectories from infancy to adolescence and finds that an autism diagnosis and specific autistic traits (repetitive behavior, speech coherence, and social communication), but not the autism polygenic score or sociability, are associated with shorter sleep trajectories, underscoring the need for early, sustained, and trait-specific sleep interventions.
This study analyzes U.S. CPSC data from 2011 to 2021 to demonstrate that aerosol duster products containing 1,1-difluoroethane are the predominant cause of inhalant abuse deaths, accounting for approximately 86% of reported cases while significantly underestimating the true prevalence due to reporting delays.
This study identifies decreasing intra-hippocampal connectivity as a specific, prognostic neural marker that precedes and predicts the worsening of negative symptoms and functional decline in individuals at clinical high risk for psychosis.
This study demonstrates that the Affect Score is a robust predictor of emerging depression and anxiety in college freshmen, while the Trier Social Stress Test (TSST) provides an independent neuroendocrine predictor specifically for anxiety in females, characterized by elevated and delayed cortisol responses.
By analyzing nearly 30,000 probands, this study identifies six distinct clusters of neurodevelopmental disorder genes that correspond to specific combinations of clinical phenotypes and underlying biological mechanisms, offering a refined framework for understanding genetic overlap and guiding future therapeutic strategies.
Using a system dynamics model calibrated to national survey data, this study reveals that while depression prevalence in South Africa has remained relatively stable from 2002 to 2024, antidepressant use remains low overall with a stark disparity between the private and public health sectors.
This paper introduces an extension of the PathGPS method that adjusts for background covariance to mitigate confounding effects like sample overlap, thereby revealing a more accurate and interpretable shared genetic architecture across 15 neurodevelopmental and neurodegenerative disorders.
This paper presents preliminary evidence from a pooled analysis of three prospective studies demonstrating that the EMOCARE-derived depressive symptom severity score, obtained via passive multimodal remote monitoring, exhibits moderate-to-strong convergent validity and sensitivity to change when compared against established clinician- and self-reported scales like the MADRS and PHQ-9 in adults with mood disorders.
This study demonstrates that while individual linguistic and cognitive measures lack consistent diagnostic sensitivity for Developmental Language Disorder (DLD), a polythetic elastic net regression model effectively integrates multiple features to capture individual variability and accurately identify both clinical and subclinical DLD cases.
This study introduces a norm-anchored structural deviation framework (NCSD) that characterizes cognitive heterogeneity in schizophrenia through global deviation from a healthy control-derived cognitive structure and specific alterations in executive loading patterns and correlation structures, offering a refined tool for precision psychiatry and functional recovery.
Using UK Biobank data, this study reveals that individuals with bipolar disorder who have an evening chronotype exhibit significantly larger volumes in the circadian-regulating anterior-inferior hypothalamic region compared to their morning chronotype counterparts, a structural difference not observed in other psychiatric diagnoses or hypothalamic subunits.
This study developed and validated a brief, 6-item screener derived from the PCL-5 that demonstrates high accuracy and sensitivity for detecting childbirth-related PTSD, offering a practical tool for integration into routine postpartum care.
The paper introduces and validates GAMBIT, a scalable, online digital training tool that successfully engages preemptive, proactive, and reactive inhibitory control mechanisms within affective contexts, demonstrating both performance improvements and enhanced self-reported temper control across multiple sessions.
A survey of 55 individuals at clinical high risk for psychosis found that cannabidiol (CBD) is a highly acceptable treatment option, with most participants familiar with the compound, willing to use it, and anticipating fewer side effects compared to existing medications.
The study demonstrates that the semi-automated actiSleep pipeline, which integrates event markers, diaries, light, and activity data, accurately estimates rest intervals in adolescents comparable to standard hand-scoring while outperforming purely activity-based algorithms, offering a viable alternative for large-scale research.
This randomized crossover study demonstrates that while naltrexone does not block ketamine-induced increases in regional cerebral blood flow in major depressive disorder, it disrupts the associations between these hemodynamic changes and both subjective effects and antidepressant response, suggesting that opioidergic modulation interacts with glutamatergic and GABAergic systems to influence ketamine's therapeutic mechanisms.
This study demonstrates that young people with emerging mental disorders exhibit reduced dim light sensitivity and slower pupil constriction compared to healthy controls, with these altered pupillary responses correlating with delayed sleep timing and specific clinical features such as bipolar genetic risk and insomnia.
This study demonstrates that in-scanner head motion is a significant confounding factor in structural MRI analyses of schizophrenia, accounting for a substantial portion of observed grey matter differences between patients and controls and suggesting that many reported morphometric findings may be motion-driven artifacts rather than true tissue properties.